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Article

Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis

12 Jan 2021

Abstract excerpt

P14ARF (ARF; Alternative Reading Frame) is an extensively characterized tumor suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis via p53-dependent and independent routes. ARF has been shown to be frequently lost through CpG island promoter methylation in a wide spectrum of human malignancies, such as colorectal, prostate, breast, and gastric cancers, while point mutations...

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PMID: 33445626
DOI: 10.3390/biom11010086

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