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Deconvolution of cancer methylation patterns determines that altered methylation in cancer is dominated by a non-disease associated proliferation signal

2024-08-23

Abstract excerpt

All cancers are associated with massive reorganisation of cellular epigenetic patterns, including extensive changes in the genomic patterns of DNA methylation. However, the huge scale of these changes has made it very challenging to identify key DNA methylation changes responsible for driving cancer development. Here, we present a novel approach to address this problem called methylation mapping. Through compariso...

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Literature Corpus work: d494e457-64cf-5a6b-bd5f-c02f4f3f216f
DOI: 10.1101/2024.08.22.609153

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