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Article

Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.

Nucleic acids research - 2 Nov 2016

Northam Matthew R, Trujillo Kelly M

Abstract excerpt

Histone modifications play an important role in regulating access to DNA for transcription, DNA repair and DNA replication. A central player in these events is the mono-ubiquitylation of histone H2B (H2Bub1), which has been shown to regulate nucleosome dynamics. Previously, it was shown that H2Bub1 was important for nucleosome assembly onto nascent DNA at active replication forks. In the absence of H2Bub1,...

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PMID: 27458205
DOI: 10.1093/nar/gkw658
PMCID: PMC5100568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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