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E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

10 Jul 2024

Abstract excerpt

Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that damage DNA. Therefore, cells are heavily reliant on DNA repair pathways that have evolved to deal with every type of genotoxic insult that threatens to compromise genome stability. Notably, inherited mutations in...

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Cancer-related Molecular Pathways
DNA Repair Mechanisms
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38985307
DOI: 10.1042/bcj20240124

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