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Article

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.

PLoS genetics - 1 Dec 2007

Alvaro David, Lisby Michael, Rothstein Rodney

Abstract excerpt

To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells. More than half of the genes are conserved across species ranging from yeast to humans. Along with genes involved in DNA replication, repair, and chromatin remodeling, we found 22 previously...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18085829
DOI: 10.1371/journal.pgen.0030228
PMCID: PMC2134942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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