Article
H2B ubiquitylation and the histone chaperone Asf1 cooperatively mediate the formation and maintenance of heterochromatin silencing.
Nucleic acids research - 21 Aug 2017
Wu Meng-Ying, Lin Chia-Yeh, Tseng Hsin-Yi, Hsu Fei-Man, Chen Pao-Yang, Kao Cheng-Fu
Abstract excerpt
Heterochromatin is a heritable form of gene repression, with critical roles in development and cell identity. Understanding how chromatin factors results in such repression is a fundamental question. Chromatin is assembled and disassembled during transcription, replication and repair by anti-silencing function 1 (Asf1), a highly conserved histone chaperone. Transcription and DNA replication are also affected by...
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