Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.

PLoS genetics - 1 Oct 2014

Lin Chia-Yeh, Wu Meng-Ying, Gay Sophie, Marjavaara Lisette, Lai Mong Sing, Hsiao Wei-Chun, Hung Shih-Hsun, Tseng Hsin-Yi, Wright Duncan Edward, Wang Chen-Yi, Hsu Guoo-Shyng W, Devys Didier, Chabes Andrei, Kao Cheng-Fu

Abstract excerpt

The influence of mono-ubiquitylation of histone H2B (H2Bub) on transcription via nucleosome reassembly has been widely documented. Recently, it has also been shown that H2Bub promotes recovery from replication stress; however, the underling molecular mechanism remains unclear. Here, we show that H2B ubiquitylation coordinates activation of the intra-S replication checkpoint and chromatin re-assembly, in order to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Hydroxyurea

Share to Molecular Chaperones

Share to Nucleosomes

Share to RecQ Helicases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 25275495
DOI: 10.1371/journal.pgen.1004667
PMCID: PMC4183429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly.PMID 25275495Read ↗

Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.Semantic proximity Read ↗

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage ResponseSemantic proximity Read ↗

E3 ligases: a ubiquitous link between DNA repair, DNA replication and human diseaseSemantic proximity Read ↗

BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stressSemantic proximity Read ↗

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responsesSemantic proximity Read ↗

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathwaysSemantic proximity Read ↗

Gene body H2B monoubiquitylation regulates gene-selective RNA Polymerase II pause release and is not rate limiting for transcription elongationSemantic proximity Read ↗

A p53-dependent FBXO44-RAD18 axis limits mutagenesis by terminating translesion DNA synthesisSemantic proximity Read ↗

HUWE1 interacts with PCNA to alleviate replication stress.Semantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

H2B ubiquitylation and the histone chaperone Asf1 cooperatively mediate the formation and maintenance of heterochromatin silencing.Semantic proximity Read ↗

H2B oncohistones cause homologous recombination defect and genomic instability through reducing H2B monoubiquitination in Schizosaccharomyces pombe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.