Article
Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.
Molecular cell - 7 Sept 2017
Vujanovic Marko, Krietsch Jana, Raso Maria Chiara, Terraneo Nastassja, Zellweger Ralph, Schmid Jonas A, Taglialatela Angelo, Huang Jen-Wei, Holland Cory L, Zwicky Katharina, Herrador Raquel, Jacobs Heinz, Cortez David, Ciccia Alberto, Penengo Lorenza, Lopes Massimo
Abstract excerpt
DNA damage tolerance during eukaryotic replication is orchestrated by PCNA ubiquitination. While monoubiquitination activates mutagenic translesion synthesis, polyubiquitination activates an error-free pathway, elusive in mammals, enabling damage bypass by template switching. Fork reversal is driven in vitro by multiple enzymes, including the DNA translocase ZRANB3, shown to bind polyubiquitinated PCNA. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.