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Article

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis

20 Jun 2020

Abstract excerpt

The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4's activity has been implicated in the pathogenesis of a wide variety of cancers. While blocking BRD4 interaction with acetylated histones using BET inhibitors (BETis) has been tested in clinical trials, many cancers have acquired BETi resistance....

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PMID: 32575711
DOI: 10.3390/cancers12061637

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