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Functional Roles of Bromodomain Proteins in Cancer

19 Jul 2021

Abstract excerpt

Histone acetylation is generally associated with an open chromatin configuration that facilitates many cellular processes including gene transcription, DNA repair, and DNA replication. Aberrant levels of histone lysine acetylation are associated with the development of cancer. Bromodomains represent a family of structurally well-characterized effector domains that recognize acetylated lysines in chromatin. As...

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PMID: 34298819
DOI: 10.3390/cancers13143606

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