Metabolomic and Genome‐wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1

Abstract excerpt

Transporter‐mediated drug‐drug interactions (DDIs) are a major cause of drug toxicities. Using published genome‐wide association studies (GWAS) of the human metabolome, we identified 20 metabolites associated with genetic variants in organic anion transporter, OATP1B1 ( P < 5 × 10 −8 ). Of these, 12 metabolites were significantly higher in plasma samples from volunteers dosed with the OATP1B1 inhibitor,...

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