Article
Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions.
Biochemical pharmacology - 15 Sept 2017
Muhrez Kienana, Largeau Bérenger, Emond Patrick, Montigny Frédéric, Halimi Jean-Michel, Trouillas Patrick, Barin-Le Guellec Chantal
Abstract excerpt
The ATP-binding cassette family transporter MRP2 (multidrug resistance-associated protein 2), encoded by the ABCC2 gene, is involved in the renal excretion of numerous xenobiotics and it is likely that it also transports many endogenous molecules arising from not only normal essential metabolic processes but also from environmental toxins or food intake. We used a targeted gas chromatography-mass spectrometry...
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