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Article

Non-targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function.

Clinical and translational science - 1 Mar 2024

Hämäläinen Kreetta, Hirvensalo Päivi, Neuvonen Mikko, Tornio Aleksi, Backman Janne T, Lehtonen Marko, Niemi Mikko

Abstract excerpt

Our aim was to evaluate biomarkers for organic anion transporting polypeptide 1B1 (OATP1B1) function using a hypothesis-free metabolomics approach. We analyzed fasting plasma samples from 356 healthy volunteers using non-targeted metabolite profiling by liquid chromatography high-resolution mass spectrometry. Based on SLCO1B1 genotypes, we stratified the volunteers to poor, decreased, normal, increased, and...

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Biomarkers
Genotype
Glucuronides
Liver-Specific Organic Anion Transporter 1
Organic Anion Transporters

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PMID: 38515340
DOI: 10.1111/cts.13773
PMCID: PMC10958181

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