Article
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.
Nature communications - 12 Jun 2015
Draisma Harmen H M, Pool René, Kobl Michael, Jansen Rick, Petersen Ann-Kristin, Vaarhorst Anika A M, Yet Idil, Haller Toomas, Demirkan Ayşe, Esko Tõnu, Zhu Gu, Böhringer Stefan, Beekman Marian, van Klinken Jan Bert, Römisch-Margl Werner, Prehn Cornelia, Adamski Jerzy, de Craen Anton J M, van Leeuwen Elisabeth M, Amin Najaf, Dharuri Harish, Westra Harm-Jan, Franke Lude, de Geus Eco J C, Hottenga Jouke Jan, Willemsen Gonneke, Henders Anjali K, Montgomery Grant W, Nyholt Dale R, Whitfield John B, Penninx Brenda W, Spector Tim D, Metspalu Andres, Slagboom P Eline, van Dijk Ko Willems, 't Hoen Peter A C, Strauch Konstantin, Martin Nicholas G, van Ommen Gert-Jan B, Illig Thomas, Bell Jordana T, Mangino Massimo, Suhre Karsten, McCarthy Mark I, Gieger Christian, Isaacs Aaron, van Duijn Cornelia M, Boomsma Dorret I
Abstract excerpt
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7,478 individuals of European descent, we find 4,068 genome- and...
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