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Endogenous Metabolites-Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity.

Clinical pharmacology and therapeutics - 1 Oct 2018

Martinez David, Muhrez Kienana, Woillard Jean-Baptiste, Berthelot Aline, Gyan Emmanuel, Choquet Sylvain, Andrès Christian R, Marquet Pierre, Barin-Le Guellec Chantal

Abstract excerpt

Although OATP1B1 is not expressed in the kidney, polymorphisms in SLCO1B1 have been associated with methotrexate clearance or toxicity. This unexpected pharmacogenetic association may reflect remote communication between liver and kidney transporters. This study confirms the pharmacogenetic association with methotrexate toxicity in adult patients with hematological malignancies. Using a targeted urinary...

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Antimetabolites, Antineoplastic
Gas Chromatography-Mass Spectrometry
Hematologic Neoplasms
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organic Anion Transporters, Sodium-Independent

Pharmacogenomic Variants

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PMID: 29285751
DOI: 10.1002/cpt.1008

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