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Article

Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.

Expert opinion on drug metabolism & toxicology - 1 Mar 2012

Clarke John D, Cherrington Nathan J

Abstract excerpt

INTRODUCTION: Organic anion transporting polypeptide (OATP) uptake transporters are important for the disposition of many drugs and perturbed OATP activity can contribute to adverse drug reactions (ADRs). It is well documented that both genetic and environmental factors can alter OATP expression and activity. Genetic factors include single nucleotide polymorphisms (SNPs) that change OATP activity and epigenetic...

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Biological Transport
Drug Interactions
Drug-Related Side Effects and Adverse Reactions
Environment
Liver Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organic Cation Transport Proteins

Pharmaceutical Preparations

Structure-Activity Relationship

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Identifiers

PMID: 22280100
DOI: 10.1517/17425255.2012.656087
PMCID: PMC3753226

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