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Article

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.

Clinical and translational science - 1 Jul 2019

Yee Sook Wah, Giacomini Marilyn M, Shen Hong, Humphreys W Griffith, Horng Howard, Brian William, Lai Yurong, Kroetz Deanna L, Giacomini Kathleen M

Abstract excerpt

Understanding transporter-mediated drug-drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)-I, and CP-III as clinical biomarkers for evaluating organic anion-transporting polypeptide (OATP)1B1 (SLCO1B1) inhibition. The current study investigated the effect of OATP1B1 genotype c.521T>C...

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Identifiers

PMID: 30982223
DOI: 10.1111/cts.12625
PMCID: PMC6662551

Genes

CP
SLCO1B1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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