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Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.

Clinical pharmacology and therapeutics - 1 Mar 2021

Neuvonen Mikko, Hirvensalo Päivi, Tornio Aleksi, Rago Brian, West Mark, Lazzaro Sarah, Mathialagan Sumathy, Varma Manthena, Cerny Matthew A, Costales Chester, Ramanathan Ragu, Rodrigues A David, Niemi Mikko

Abstract excerpt

The aim of this study was to investigate the sensitivity and specificity of endogenous glycochenodeoxycholate and glycodeoxycholate 3-O-glucuronides (GCDCA-3G and GDCA-3G) as substrates for organic anion transporting polypeptide 1B1 (OATP1B1) in humans. We measured fasting levels of plasma GCDCA-3G and GDCA-3G using liquid chromatography-tandem mass spectrometry in 356 healthy volunteers. The mean plasma levels...

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Identifiers

PMID: 32961594
DOI: 10.1002/cpt.2053
PMCID: PMC7983942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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