Article
Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.
Biogerontology - 1 Nov 2016
Kulminski Alexander M, Raghavachari Nalini, Arbeev Konstantin G, Culminskaya Irina, Arbeeva Liubov, Wu Deqing, Ukraintseva Svetlana V, Christensen Kaare, Yashin Anatoliy I
Abstract excerpt
The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We examine potential pleiotropic associations of the apoE2 allele in three biodemographic cohorts of long-living individuals, offspring, and spouses from the Long Life Family Study, and intermediate mechanisms, which can link this allele with age-related phenotypes. We focused on age-related macular degeneration, bronchitis,...
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