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Article

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

PLoS genetics - 1 Jan 2014

Kulminski Alexander M, Arbeev Konstantin G, Culminskaya Irina, Arbeeva Liubov, Ukraintseva Svetlana V, Stallard Eric, Christensen Kaare, Schupf Nicole, Province Michael A, Yashin Anatoli I

Abstract excerpt

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham Heart Study (FHS) original and offspring cohorts and the Long Life Family Study (LLFS) to investigate gender-specific effects of the ApoE4 allele on human...

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Identifiers

PMID: 24497847
DOI: 10.1371/journal.pgen.1004141
PMCID: PMC3907310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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