Article
Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.
PLoS genetics - 1 Nov 2016
Kulminski Alexander M, He Liang, Culminskaya Irina, Loika Yury, Kernogitski Yelena, Arbeev Konstantin G, Loiko Elena, Arbeeva Liubov, Bagley Olivia, Duan Matt, Yashkin Arseniy, Fang Fang, Kovtun Mikhail, Ukraintseva Svetlana V, Wu Deqing, Yashin Anatoliy I
Abstract excerpt
Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene studies. Genome-wide scan in the Atherosclerosis Risk in Communities (ARIC) Study (N = 9,573) was used to pre-select promising loci. Candidate-gene methods were used to...
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