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Article

The ApoE Locus and COVID-19: Are We Going Where We Have Been?

10 Aug 2020

Abstract excerpt

Four decades ago in 1985, alleles of apolipoprotein E (ApoE) ε2/ε3/ε4 became famous for explaining 16% of genetic variance in low-density lipoprotein cholesterol in the benchmark study of Sing and Davignon (1): total blood cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B were elevated by ApoE ε4 (ApoE4) allele and lowered by ApoE ε2 (ApoE2). The adverse associations of ApoE4 with...

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PMID: 32777042
DOI: 10.1093/gerona/glaa200

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