Article
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
Rejuvenation research - 1 Apr 2015
Kulminski Alexander M, Arbeev Konstantin G, Culminskaya Irina, Ukraintseva Svetlana V, Stallard Eric, Province Michael A, Yashin Anatoli I
Abstract excerpt
The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused on long-living participants of the Long Life Family Study (LLFS), their offspring, and spouses to: (1) Elucidate whether trade-offs in the effect of the apolipoprotein E e4 allele documented...
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