Article
Apolipoprotein E and familial longevity.
Neurobiology of aging - 1 Apr 2013
Schupf Nicole, Barral Sandra, Perls Thomas, Newman Anne, Christensen Kaare, Thyagarajan Bharat, Province Michael, Rossi Winifred K, Mayeux Richard
Abstract excerpt
Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently. Offspring from long-lived families and spouse controls were recruited at 3 sites in the United States and Denmark. We used generalized estimating...
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