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Article

The influence of the COMT genotype in the underlying functional brain activity of context processing in schizophrenia and in relatives.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Nov 2016

Lopez-Garcia Pilar, Cristobal-Huerta Alexandra, Young Espinoza Leslie, Molero Patricio, Ortuño Sanchez-Pedreño Felipe, Hernández-Tamames Juan Antonio

Abstract excerpt

UNLABELLED: Context processing deficits have been shown to be present in chronic and first episode schizophrenia patients and in their relatives. This cognitive process is linked to frontal functioning and is highly dependent on dopamine levels in the prefrontal cortex (PFC). The catechol-O-methyltransferase (COMT) enzyme plays a prominent role in regulating dopamine levels in PFC. Genotypic variations in the...

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Source

Identifiers

PMID: 27421706
DOI: 10.1016/j.pnpbp.2016.07.005

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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