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Article

Impact of COMT genotype on cognition in schizophrenia spectrum patients and their relatives.

Psychiatry research - 30 Jul 2013

Lopez-Garcia Pilar, Young Espinoza Leslie, Molero Santos Patricio, Marin Juan, Ortuño Sanchez-Pedreño Felipe

Abstract excerpt

Cognitive impairment in schizophrenia is a core feature and seems to be related mainly to dopaminergic dysfunction in the prefrontal cortex (PFC). The functional polymorphism Val158Met of the COMT (catechol-O-methyltransferase) gene could mediate the relationship between cognition and dopamine activity in PFC. The present study tested the influence of this polymorphism on the cognitive performance of...

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Source

Identifiers

PMID: 23102922
DOI: 10.1016/j.psychres.2012.09.043

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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