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Article

Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood.

NeuroImage - 15 May 2016

Boecker-Schlier Regina, Holz Nathalie E, Buchmann Arlette F, Blomeyer Dorothea, Plichta Michael M, Jennen-Steinmetz Christine, Wolf Isabella, Baumeister Sarah, Treutlein Jens, Rietschel Marcella, Meyer-Lindenberg Andreas, Banaschewski Tobias, Brandeis Daniel, Laucht Manfred

Abstract excerpt

BACKGROUND: Accumulating evidence suggests that altered dopamine transmission may increase the risk of mental disorders such as ADHD, schizophrenia or depression, possibly mediated by reward system dysfunction. This study aimed to clarify the impact of the COMT Val(158)Met polymorphism in interaction with environmental variation (G×E) on neuronal activity during reward processing. METHODS: 168 healthy young...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26879624
DOI: 10.1016/j.neuroimage.2016.02.006

Genes

COMT

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