Article
Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli.
Psychological medicine - 1 Feb 2013
Lo Bianco L, Blasi G, Taurisano P, Di Giorgio A, Ferrante F, Ursini G, Fazio L, Gelao B, Romano R, Papazacharias A, Caforio G, Sinibaldi L, Popolizio T, Bellantuono C, Bertolino A
Abstract excerpt
BACKGROUND: Emotion dysregulation is a key feature of schizophrenia, a brain disorder strongly associated with genetic risk and aberrant dopamine signalling. Dopamine is inactivated by catechol-O-methyltransferase (COMT), whose gene contains a functional polymorphism (COMT Val158Met) associated with differential activity of the enzyme and with brain physiology of emotion processing. The aim of the present study...
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