Article
Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.
Nucleic acids research - 6 Sept 2016
Spengler Ryan M, Zhang Xiaoming, Cheng Congsheng, McLendon Jared M, Skeie Jessica M, Johnson Frances L, Davidson Beverly L, Boudreau Ryan L
Abstract excerpt
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a...
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