Article
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
The Journal of clinical investigation - 1 Aug 2014
Maatz Henrike, Jens Marvin, Liss Martin, Schafer Sebastian, Heinig Matthias, Kirchner Marieluise, Adami Eleonora, Rintisch Carola, Dauksaite Vita, Radke Michael H, Selbach Matthias, Barton Paul J R, Cook Stuart A, Rajewsky Nikolaus, Gotthardt Michael, Landthaler Markus, Hubner Norbert
Abstract excerpt
Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through altering cardiac RNA splicing. Here, we combined transcriptome-wide crosslinking immunoprecipitation (CLIP-seq), RNA-seq, and quantitative proteomics in cell culture and rat and human hearts to examine how RBM20 regulates alternative splicing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.