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Article

Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.

Molecular cell - 3 Aug 2017

Luna Joseph M, Barajas Juan M, Teng Kun-Yu, Sun Hui-Lung, Moore Michael J, Rice Charles M, Darnell Robert B, Ghoshal Kalpana

Abstract excerpt

MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28735896
DOI: 10.1016/j.molcel.2017.06.025
PMCID: PMC5603316

Genes

BCL9

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