Article

Identifying cardiac actinin interactomes reveals sarcomere crosstalk with RNA-binding proteins

2020-03-19

Abstract excerpt

<h4>Rationale</h4> Actinins are actin cross-linkers that are ubiquitously expressed and harbor mutations in heritable diseases. The predominant cardiac actinin is encoded by ACTN2 , which is a core structural component of the sarcomere Z-disk. ACTN2 is required for sarcomere function through complex interactions with proteins involved in sarcomere assembly, cell signaling and transcriptional regulation. However,...

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Literature Corpus work: ff161453-f71f-5f94-a798-ffee342821cb
DOI: 10.1101/2020.03.18.994004

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