Article

Muscle LIM Protein is a Non-Canonical RNA-Binding Protein that Engages in RNA-Dependent Cytoskeletal Assembly

2026-03-15

Abstract excerpt

<h4>Summary</h4> Muscle LIM Protein (MLP) is a key component of the cardiomyocyte Z disc that is essential for sarcomere integrity and cardiac homeostasis. Accordingly, loss of MLP function results in (cardio)myopathy phenotypes in animal models and human patients. In this study, we present the first RNA-binding proteome (RBPome) of human cardiomyocytes using enhanced RNA interactome capture (eRIC). Data integrat...

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Literature Corpus work: df196c3c-036b-5d36-be54-3e27ddbbcdd6
DOI: 10.64898/2026.03.10.710776

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