Article

CLASHub: an integrated database and analytical platform for microRNA-target interactions

2025-08-07

Abstract excerpt

MicroRNAs (miRNAs) are ∼22-nucleotide RNAs that regulate gene expression, critical for development and disease. Residing in Argonaute (AGO) proteins, miRNAs target messenger RNAs via complementary base-pairing. Current miRNA-target databases rely on indirect data from AGO crosslinking immunoprecipitation (AGO-CLIP). In contrast, CLASH (Crosslinking, Ligation, and Sequencing of Hybrids) employs proximity ligation w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acb70068-780a-50a2-9cf9-481c10961088
DOI: 10.1101/2025.08.05.668543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CLASHub: an integrated database and analytical platform for microRNA-target interactionsDOI 10.1101/2025.08.05.668543Read

MUTACLASH: identifying functional small RNA target sites using crosslinking-induced mutations.Semantic proximity Read

MtiBase: a database for decoding microRNA target sites located within CDS and 5'UTR regions from CLIP-Seq and expression profile datasets.Semantic proximity Read

miRge 2.0: An updated tool to comprehensively analyze microRNA sequencing dataSemantic proximity Read

Beyond microRNAs: Analysis of chimeric reads characterises the diverse targetome of AGO2-mediated regulationSemantic proximity Read

PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways.Semantic proximity Read

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.Semantic proximity Read

Systematic mapping of small nucleolar RNA targets in human cellsSemantic proximity Read

agoTRIBE detects miRNA-target interactions transcriptome-wide in single cellsSemantic proximity Read

Benchmarking microRNA Target Prediction Algorithms Using Single-Cell Co-Sequencing DataSemantic proximity Read

miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions.Semantic proximity Read

Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.Semantic proximity Read

MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases.Semantic proximity Read