Article
Integrated transcriptomic and regulatory network analyses identify microRNA-200c as a novel repressor of human pluripotent stem cell-derived cardiomyocyte differentiation and maturation.
Cardiovascular research - 1 May 2018
Poon Ellen Ngar-Yun, Hao Baixia, Guan Daogang, Jun Li Mulin, Lu Jun, Yang Yong, Wu Binbin, Wu Stanley Chun-Ming, Webb Sarah E, Liang Yan, Miller Andrew L, Yao Xiaoqiang, Wang Junwen, Yan Bin, Boheler Kenneth R
Abstract excerpt
Aims: MicroRNAs (miRNAs) are crucial for the post-transcriptional control of protein-encoding genes and together with transcription factors (TFs) regulate gene expression; however, the regulatory activities of miRNAs during cardiac development are only partially understood. In this study, we tested the hypothesis that integrative computational approaches could identify miRNAs that experimentally could be shown to...
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