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Article

Structural Determinants of Sleeping Beauty Transposase Activity.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2016

Abrusán György, Yant Stephen R, Szilágyi András, Marsh Joseph A, Mátés Lajos, Izsvák Zsuzsanna, Barabás Orsolya, Ivics Zoltán

Abstract excerpt

Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called "sectors", which have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27401040
DOI: 10.1038/mt.2016.110
PMCID: PMC5010145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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