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Article

MuA transposase separates DNA sequence recognition from catalysis.

Biochemistry - 16 Dec 2003

Goldhaber-Gordon Ilana, Early Michael H, Baker Tania A

Abstract excerpt

Confronted with thousands of potential DNA substrates, a site-specific enzyme must restrict itself to the correct DNA sequence. The MuA transposase protein performs site-specific DNA cleavage and joining reactions, resulting in DNA transposition-a specialized form of genetic recombination. To determine how sequence information is used to restrict transposition to the proper DNA sites, we performed kinetic...

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PMID: 14661976
DOI: 10.1021/bi035360o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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