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Article

Functional zinc finger/sleeping beauty transposase chimeras exhibit attenuated overproduction inhibition.

FEBS letters - 7 Nov 2005

Wilson Matthew H, Kaminski Joseph M, George Alfred L

Abstract excerpt

The sleeping beauty (SB) transposon system has potential utility in gene transfer applications but lacks specificity for genomic integration and exhibits overproduction inhibition which limits in vivo activity. Targeting transposition may be possible by coupling a specific DNA binding domain to the SB transposase, but it is not known if this strategy will preserve or disrupt activity of the system. We engineered...

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PMID: 16243318
DOI: 10.1016/j.febslet.2005.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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