Article
The next generation of target capture technologies - large DNA fragment enrichment and sequencing determines regional genomic variation of high complexity.
BMC genomics - 9 Jul 2016
Dapprich Johannes, Ferriola Deborah, Mackiewicz Kate, Clark Peter M, Rappaport Eric, D'Arcy Monica, Sasson Ariella, Gai Xiaowu, Schug Jonathan, Kaestner Klaus H, Monos Dimitri
Abstract excerpt
BACKGROUND: The ability to capture and sequence large contiguous DNA fragments represents a significant advancement towards the comprehensive characterization of complex genomic regions. While emerging sequencing platforms are capable of producing several kilobases-long reads, the fragment sizes generated by current DNA target enrichment technologies remain a limiting factor, producing DNA fragments generally...
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