Article
dCATCH-Seq: improved sequencing of large continuous genomic targets with double-hybridization.
BMC genomics - 23 Oct 2017
Zhang Yanfeng, Song Jun, Day Kenneth, Absher Devin
Abstract excerpt
BACKGROUND: Targeted sequencing is a powerful tool with broad application in both basic and translational sciences. Relatively low on-target rates for most current targeted sequencing studies influence the required coverage and data quality for subsequent applications. RESULTS: We present an improved targeted sequencing method that uses two rounds of in solution hybridization with probes synthesized from genomic...
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