Characterizing alleles with large deletions using region specific extraction.

doi:10.1016/j.humimm.2018.03.005

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Article

Characterizing alleles with large deletions using region specific extraction.

Human immunology - 1 Jun 2018

Steiner Noriko K, Hou Lihua, Hurley Carolyn Katovich

Abstract excerpt

Two novel HLA class II alleles, DRB4*03:01N and DQB1*03:276N, containing large deletions were identified during routine typing. Extraction of DNA encompassing the deletions was carried out with a panel of capture oligonucleotides followed by whole genome amplification. Next generation DNA sequencing was then used to characterize the sequences. DRB4*03:01N has a 16 kilobase pair deletion stretching upstream from...

Topics

Alleles
DNA Primers
Genome
Genome Components
Genotype
HLA-DQ beta-Chains
HLA-DRB4 Chains
Histocompatibility Testing
Humans
Introns
Polymorphism, Genetic
Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 29580811
DOI: 10.1016/j.humimm.2018.03.005

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