Article

Targeted long-read sequencing facilitates phased diploid assembly and genotyping of the human T cell receptor alpha, delta and beta loci

2022-05-25

Abstract excerpt

T cell receptors (TCRs) recognize peptide fragments presented by the major histocompatibility complex (MHC) and are critical to T cell mediated immunity. Early studies demonstrated an enrichment of polymorphisms within TCR-encoding (TR) gene loci. However, more recent data indicate that variation in these loci are underexplored, limiting understanding of the impact of TR polymorphism on TCR function in disease, ev...

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Identifiers and source

Literature Corpus work: 94593250-8856-59e3-b575-d4bd512dcf84
DOI: 10.1101/2022.05.24.493244

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