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Article

Perpetuating the homing endonuclease life cycle: identification of mutations that modulate and change I-TevI cleavage preference.

Nucleic acids research - 6 Sept 2016

Roy Alexander C, Wilson Geoffrey G, Edgell David R

Abstract excerpt

Homing endonucleases are sequence-tolerant DNA endonucleases that act as mobile genetic elements. The ability of homing endonucleases to cleave substrates with multiple nucleotide substitutions suggests a high degree of adaptability in that changing or modulating cleavage preference would require relatively few amino acid substitutions. Here, using directed evolution experiments with the GIY-YIG homing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27387281
DOI: 10.1093/nar/gkw614
PMCID: PMC5009752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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