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Article

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences.

Nucleic acids research - 1 Jan 2006

Smith Julianne, Grizot Sylvestre, Arnould Sylvain, Duclert Aymeric, Epinat Jean-Charles, Chames Patrick, Prieto Jesús, Redondo Pilar, Blanco Francisco J, Bravo Jerónimo, Montoya Guillermo, Pâques Frédéric, Duchateau Philippe

Abstract excerpt

Meganucleases, or homing endonucleases (HEs) are sequence-specific endonucleases with large (>14 bp) cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells and plants. These findings have opened novel perspectives for genome engineering in a wide range of fields, including gene therapy. However, the number of identified HEs does not match the diversity of genomic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17130168
DOI: 10.1093/nar/gkl720
PMCID: PMC1702487

Genes

RAG1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences.PMID 17130168Read ↗

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Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease.Semantic proximity Read ↗

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Double-strand break-induced targeted mutagenesis in plants.Semantic proximity Read ↗

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