Article
Distance determination by GIY-YIG intron endonucleases: discrimination between repression and cleavage functions.
Nucleic acids research - 1 Jan 2006
Liu Qingqing, Derbyshire Victoria, Belfort Marlene, Edgell David R
Abstract excerpt
GIY-YIG homing endonucleases are modular proteins, with conserved N-terminal catalytic domains connected by linkers to C-terminal DNA-binding domains. I-TevI, the T4 phage GIY-YIG intron endonuclease, functions both in promoting td intron homing, and in acting as a transcriptional autorepressor. Repression is achieved by binding to an operator, which is cleaved at 100-fold reduced efficiency relative to the...
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