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Article

Tapping natural reservoirs of homing endonucleases for targeted gene modification

22 Jul 2011

Abstract excerpt

Homing endonucleases mobilize their own genes by generating double-strand breaks at individual target sites within potential host DNA. Because of their high specificity, these proteins are used for "genome editing" in higher eukaryotes. However, alteration of homing endonuclease specificity is quite challenging. Here we describe the identification and phylogenetic analysis of over 200 naturally occurring...

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PMID: 21784983
DOI: 10.1073/pnas.1107719108

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Tapping natural reservoirs of homing endonucleases for targeted gene modificationPMID 21784983Read ↗

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