Article
A systems biology framework identifies molecular underpinnings of coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2013
Huan Tianxiao, Zhang Bin, Wang Zhi, Joehanes Roby, Zhu Jun, Johnson Andrew D, Ying Saixia, Munson Peter J, Raghavachari Nalini, Wang Richard, Liu Poching, Courchesne Paul, Hwang Shih-Jen, Assimes Themistocles L, McPherson Ruth, Samani Nilesh J, Schunkert Heribert, Meng Qingying, Suver Christine, O'Donnell Christopher J, Derry Jonathan, Yang Xia, Levy Daniel
Abstract excerpt
OBJECTIVE: Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene-disease associations, however, remain unclear. We hypothesized that genetic variants with both strong and subtle effects drive gene subnetworks that in turn affect CHD. APPROACH AND RESULTS: We surveyed CHD-associated molecular interactions by constructing...
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