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Article

Identification of Mechanisms by Which Genetic Susceptibility Loci Influence Systemic Sclerosis Risk Using Functional Genomics in Primary T Cells and Monocytes.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2023

González-Serna David, Shi Chenfu, Kerick Martin, Hankinson Jenny, Ding James, McGovern Amanda, Tutino Mauro, Villanueva-Martin Gonzalo, Ortego-Centeno Norberto, Callejas José Luis, Martin Javier, Orozco Gisela

Abstract excerpt

OBJECTIVE: Systemic sclerosis (SSc) is a complex autoimmune disease with a strong genetic component. However, most of the genes associated with the disease are still unknown because associated variants affect mostly noncoding intergenic elements of the genome. We used functional genomics to translate the genetic findings into a better understanding of the disease. METHODS: Promoter capture Hi-C and RNA-sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36281738
DOI: 10.1002/art.42396
PMCID: PMC10953390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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