Article
Unraveling the genetic component of systemic sclerosis.
Human genetics - 1 Jul 2012
Martín José Ezequiel, Bossini-Castillo Lara, Martín Javier
Abstract excerpt
Systemic sclerosis (SSc) is a severe connective tissue disorder characterized by extensive fibrosis, vascular damage, and autoimmune events. During the last years, the number of genetic markers convincingly associated with SSc has exponentially increased. In this report, we aim to offer an updated review of the classical and novel genetic associations with SSc, analyzing the firmest and replicated signals within...
Topics
- Autoantibodies
- Autoimmune Diseases
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- HLA Antigens
- Humans
- Scleroderma, Systemic