Article
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
Nature genetics - 1 May 2010
Radstake Timothy R D J, Gorlova Olga, Rueda Blanca, Martin Jose-Ezequiel, Alizadeh Behrooz Z, Palomino-Morales Rogelio, Coenen Marieke J, Vonk Madelon C, Voskuyl Alexandre E, Schuerwegh Annemie J, Broen Jasper C, van Riel Piet L C M, van 't Slot Ruben, Italiaander Annet, Ophoff Roel A, Riemekasten Gabriela, Hunzelmann Nico, Simeon Carmen P, Ortego-Centeno Norberto, González-Gay Miguel A, González-Escribano María F, Airo Paolo, van Laar Jaap, Herrick Ariane, Worthington Jane, Hesselstrand Roger, Smith Vanessa, de Keyser Filip, Houssiau Fredric, Chee Meng May, Madhok Rajan, Shiels Paul, Westhovens Rene, Kreuter Alexander, Kiener Hans, de Baere Elfride, Witte Torsten, Padykov Leonid, Klareskog Lars, Beretta Lorenzo, Scorza Rafaella, Lie Benedicte A, Hoffmann-Vold Anna-Maria, Carreira Patricia, Varga John, Hinchcliff Monique, Gregersen Peter K, Lee Annette T, Ying Jun, Han Younghun, Weng Shih-Feng, Amos Christopher I, Wigley Fredrick M, Hummers Laura, Nelson J Lee, Agarwal Sandeep K, Assassi Shervin, Gourh Pravitt, Tan Filemon K, Koeleman Bobby P C, Arnett Frank C, Martin Javier, Mayes Maureen D
Abstract excerpt
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death. To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls. Analysis of 279,621 autosomal SNPs followed by...
Read the complete abstract on PubMed